STAT1-Dependent Innate Immunity to a Norwalk-like Virus

• Published in: Science (American Association for the Advancement of Science) Vol. 299; no. 5612; pp. 1575 - 1578
• Main Authors: Karst, Stephanie M., Wobus, Christiane E., Lay, Margarita, Davidson, John, Virgin, Herbert W.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 07-03-2003; The American Association for the Advancement of Science
• Subjects: Animals; B-Lymphocytes - immunology; Biological and medical sciences; Brain - virology; Caliciviridae Infections - immunology; Capsid proteins; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Epidemics; Epidemiology; Fundamental and applied biological sciences. Psychology; Genes, RAG-1; Genome, Viral; Genomes; Homeodomain Proteins - physiology; House mouse; Immunity, Innate; Immunocompromised Host; Infections; Innate immunity; Interferon gamma Receptor; Intestines - virology; Liver - virology; Membrane Proteins; Mice; Mice as laboratory animals; Microbiology; Mutation; Norovirus; Norovirus - classification; Norovirus - immunology; Norovirus - isolation & purification; Norovirus - pathogenicity; Norwalk virus; Phylogeny; Prevention; Receptor, Interferon alpha-beta; Receptors; Receptors, Interferon - genetics; Receptors, Interferon - physiology; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; RNA, Viral - analysis; Spleen - virology; STAT1 Transcription Factor; T-Lymphocytes - immunology; Trans-Activators - genetics; Trans-Activators - physiology; Viral RNA; Virology; Virulence; Viruses; United States; Animal model; Immune response; Norwalk like virus; Rodentia; Natural immunity; Host virus relation; Infection; Virus; Resistance; Transcription factor STAT1; Calicivirus; Vertebrata; Mammalia; Mouse; Caliciviridae; Viral disease
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1077905

Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.