Predominance of rotavirus P[4]G2 in a vaccinated population, Brazil

We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2....

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 13; no. 10; pp. 1571 - 1573
Main Authors:	Gurgel, Ricardo Q, Cuevas, Luis E, Vieira, Sarah C F, Barros, Vanessa C F, Fontes, Paula B, Salustino, Eduardo F, Nakagomi, Osamu, Nakagomi, Toyoko, Dove, Winifred, Cunliffe, Nigel, Hart, Charles A
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-10-2007 Centers for Disease Control and Prevention
Subjects:	Brazil Brazil - epidemiology Child Child, Preschool Cohort Studies diarrhea Dispatch Dysentery - immunology Dysentery - virology Genotype genotypes Health aspects Humans Infant Infection Mass Vaccination Rotavirus Rotavirus - classification Rotavirus - genetics Rotavirus Infections - epidemiology Rotavirus Infections - immunology Rotavirus Infections - virology Rotavirus Vaccines - immunology Vaccination vaccine Vaccines, Attenuated - immunology Brazil
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Summary:	We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9. Although virus predominance could have occurred randomly, the vaccine may be less protective against P[4]G2. Prospective surveillance is urgently needed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1310.070412