A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

• Published in: Science (American Association for the Advancement of Science) Vol. 262; no. 5130; pp. 57 - 66
• Main Authors: Copeland, Neal G., Jenkins, Nancy A., Gilbert, Debra J., Eppig, Janan T., Maltais, Lois J., Miller, Joyce C., Dietrich, William F., Weaver, Alix, Lincoln, Stephen E., Steen, Robert G., Stein, Lincoln D., Nadeau, Joseph H., Lander, Eric S.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 01-10-1993; American Association for the Advancement of Science
• Subjects: 550400 - Genetics; ANIMALS; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; BIOLOGICAL EVOLUTION; BIOLOGICAL MODELS; Chromosome Mapping; CHROMOSOMES; Classical genetics, quantitative genetics, hybrids; Cloning, Molecular; Crosses, Genetic; Disease models; Female; Fundamental and applied biological sciences. Psychology; GENES; Genetic aspects; Genetic loci; GENETIC MAPPING; Genetic Markers; Genetic mutation; Genetics of eukaryotes. Biological and molecular evolution; Genome; Genomes; House mouse; Human genetics; Human genome; Human Genome Project; Humans; Male; MAMMALS; MAPPING; Medical genetics; MICE; Mice - genetics; Multigene Family; Muridae - genetics; Mutation; Neoplasms - genetics; RODENTS; Vertebrata; VERTEBRATES; Genetic mapping; High resolution; Linkage; Biological evolution; Rodentia; Homology; Review; Vertebrata; Mammalia; Gene; Mouse; Mutation; Genome
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.8211130

Technological advances have made possible the development of high-resolution genetic linkage maps for the mouse. These maps in turn offer exciting prospects for understanding mammalian genome evolution through comparative mapping, for developing mouse models of human disease, and for identifying the function of all genes in the organism.