Structure of the Arabidopsis RPM1 gene enabling dual specificity disease resistance

• Published in: Science (American Association for the Advancement of Science) Vol. 269; no. 5225; pp. 843 - 846
• Main Authors: Grant, M.R. (Max-Delbruck Laboratory, Koln, Germany.), Godiard, L, Straube, E, Ashfield, T, Lewald, J, Sattler, A, Innes, R.W, Dang, J.L
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 11-08-1995; American Association for the Advancement of Science; The American Association for the Advancement of Science; American Association for the Advancement of Science (AAAS)
• Subjects: Alleles; Amino Acid Sequence; Arabidopsis - genetics; Arabidopsis - microbiology; Arabidopsis Proteins; ARABIDOPSIS THALIANA; Base Sequence; Biological and medical sciences; Cellular Biology; Complementation; Cosmids; Disease; Disease resistance (Plants); DNA; DNA probes; EXPRESION GENICA; EXPRESSION DES GENES; Flowers & plants; Fundamental and applied biological sciences. Psychology; GENE; GENES; Genes, Bacterial; Genes, Plant; Genes. Genome; Genetic aspects; Genetic Complementation Test; GENETICA; Genetics; GENETIQUE; Genomics; Life Sciences; Molecular and cellular biology; Molecular biology; Molecular genetics; Molecular Sequence Data; Mutation; Open Reading Frames; Pathogens; Plant Diseases - genetics; Plant growth; Plant immunology; Plant Proteins - chemistry; Plant Proteins - genetics; Plants; Plants, Genetically Modified; Polymorphism, Restriction Fragment Length; Pseudomonas - genetics; Pseudomonas - growth & development; Pseudomonas - pathogenicity; PSEUDOMONAS SYRINGAE; RESISTANCE AUX MALADIES; RESISTENCIA A LA ENFERMEDAD; Transformation, Genetic; Virulence - genetics; Pseudomonadales; Plant pathogen; Nucleotide sequence; Homology; Gene organization; Host agent relation; Gene expression; Arabidopsis thaliana; Resistance; Leucine zipper structure; Gene; Cruciferae; Pseudomonas syringae; Dicotyledones; Angiospermae; Bacteria; Pseudomonadaceae; Chromosome DNA; Spermatophyta; Mutation
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.7638602

Plants can recognize pathogens through the action of disease resistance (R) genes, which confer resistance to pathogens expressing unique corresponding avirulence (avr) genes. The molecular basis of this gene-for-gene specificity is unknown. The Arabidopsis thaliana RPM1 gene enables dual specificity to pathogens expressing either of two unrelated Pseudomonas syringae avr genes. Despite this function, RPM1 encodes a protein sharing molecular features with recently described single-specificity R genes. Surprisingly, RPM1 is lacking from naturally occurring, disease-susceptible Arabidopsis accessions