Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques

Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge wi...

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Bibliographic Details
Published in:	Nature medicine Vol. 16; no. 10; pp. 1117 - 1119
Main Authors:	Haigwood, Nancy L, Ng, Cherie T, Jaworski, J Pablo, Jayaraman, Pushpa, Sutton, William F, Delio, Patrick, Kuller, LaRene, Anderson, David, Landucci, Gary, Richardson, Barbra A, Burton, Dennis R, Forthal, Donald N
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-10-2010 Nature Publishing Group
Subjects:	631/250/2152/2153/1291 631/326/596/2553 692/699/249/1570/1901 Animals Antibodies, Neutralizing - immunology B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine brief-communication Cancer Research CD4 Lymphocyte Count Development and progression Disease control Disease transmission Dosage and administration Drug therapy HIV Human immunodeficiency virus Immunization, Passive Immunoglobulin G Immunoglobulin G - immunology Immunology Infection control Infectious Diseases Macaca Metabolic Diseases Methods Molecular Medicine Monkeys & apes Monoclonal antibodies Neonatal care Neurosciences Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Viremia Viremia - immunology Viremia - prevention & control United States
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Summary:	Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge with simian-HIV strain SF162P3 (SHIVSF162P3). All of the macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Current address: Dept. of Medicine, Harvard University, Boston MA 02115. Current address: The Scripps Research Institute, La Jolla CA 92037
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.2233