Facile synthesis of 4 H -chromene derivatives via base-mediated annulation of ortho -hydroxychalcones and 2-bromoallyl sulfones

Facile synthesis of 4 H -chromene derivatives via base-mediated annulation of ortho -hydroxychalcones and 2-bromoallyl sulfones

The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho -hydroxychalcones furnished 3-arylsulfonyl-4 H -chromene derivatives in 58–67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.

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Bibliographic Details
Published in:Beilstein journal of organic chemistry Vol. 12; pp. 16 - 21
Main Authors: Thadkapally, Srinivas, Kunjachan, Athira C, Menon, Rajeev S
Format: Journal Article
Language:English
Published: 06-01-2016
Online Access:Get full text
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Description
Summary:The cesium carbonate-mediated reaction of 2-bromoallyl sulfones and ortho -hydroxychalcones furnished 3-arylsulfonyl-4 H -chromene derivatives in 58–67% yield (18 examples). 2-Bromoallyl sulfones functioned as synthetic surrogates for allenyl sulfones in the reaction.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.12.3