Simple Identification of Cerebrospinal Fluid Turbulent Motion Using a Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession Method Applied to Various Types of Cerebrospinal Fluid Motion Disturbance

• Published in: Neurologia medico-chirurgica Vol. 60; no. 1; pp. 30 - 36
• Main Authors: ATSUMI, Hideki, HORIE, Tomohiko, KAJIHARA, Nao, SUNAGA, Azusa, SAKAKIBARA, Yumetaro, MATSUMAE, Mitsunori
• Format: Journal Article
• Language: English
• Published: Tokyo The Japan Neurosurgical Society 01-01-2020; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: Arachnoid; Blood vessels; Brain stem; Cerebrospinal fluid; dynamic improved motion-sensitized driven-equilibrium steady-state free precession; fluid dynamics; Hydrocephalus; Magnetic resonance imaging; Nerves; Original; Subarachnoid space; Therapeutic applications; Turbulence; Ventricle; Ventricles (cerebral)
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.oa.2019-0170

The motion of cerebrospinal fluid (CSF) within the subarachnoid space and ventricles is greatly modulated when propagating synchronously with the cardiac pulse and respiratory cycle and path through the nerves, blood vessels, and arachnoid trabeculae. Water molecule movement that propagates between two spaces via a stoma, foramen, or duct presents increased acceleration when passing through a narrow area and can exhibit “turbulence.” Recently, neurosurgeons have started to perform fenestration procedures using neuroendoscopy to treat hydrocephalus and cystic lesions. As part of the postoperative evaluation, a noninvasive diagnostic technique to visualize the water molecules at the fenestrated site is necessary. Because turbulence is observed at this fenestrated site, an imaging technique appropriate for observing this turbulence is essential. We therefore investigated the usefulness of a dynamic improved motion-sensitized driven-equilibrium steady-state free precession (Dynamic iMSDE SSFP) sequence of magnetic resonance imaging that is superior for ascertaining turbulent motions in healthy volunteers and patients. Images of Dynamic iMSDE SSFP from volunteers revealed that CSF motion at the ventral surface of the brainstem and the third ventricle is augmented and turbulent. Moreover, our findings confirmed that this technique is useful for evaluating treatments that utilize neuroendoscopy. As a result, Dynamic iMSDE SSFP, a simple sequence for visualizing CSF motion, entails a short imaging time, can extensively visualize CSF motion, does not require additional processes such as labeling or trigger setting, and is anticipated to have wide-ranging clinical applications in the future.