Acute respiratory infections of the upper respiratory tract, aspects of mucoactive therapy

• Published in: Medicinskij sovet no. 7; pp. 34 - 43
• Main Authors: Korkmazov, M. Yu, Kornova, N. V., Lengina, M. A., Korkmazov, A. M.
• Format: Journal Article
• Language: English
• Published: 18-05-2024
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/ms2024-046

Introduction.
Acute laryngotracheitis occurs at any age and is a complication of acute respiratory infection with a frequency of up to 40%. One of the main clinical symptoms is an unproductive paroxysmal cough. According to the literature, phytotherapy is a safe and effective part of conservative therapy and is included in clinical recommendations.
Aim.
To evaluate the effectiveness of the use of mucolytic phytopreparations in the treatment of acute respiratory infection complicated by laryngotracheitis.
Mat
erials
and methods.
A randomized simple controlled clinical trial was conducted in which 74 patients aged 18 to 45 years with acute laryngitis complicated by laryngotracheitis participated. All patients were randomly divided into 3 groups: group 1 (n = 24) received standard conservative therapy without mucolytic expectorants; group 2 (n = 25) – standard conservative therapy and acetylcysteine; group 3 (n = 25) – standard therapy using a herbal preparation based on ivy leaf extract in the form of syrup. Assessment of the severity of the main clinical symptoms and quality of life was carried out on the 5
th
, 7
th
 and 10
th
day of therapy.
Conclusions.
The use of ivy leaf extract, which has a mucolytic and expectorant effect in complex therapy in patients with acute laryngotracheitis against the background of acute respiratory viral infection, allowed us to obtain stable positive dynamics in a shorter time (5
th
 day of treatment) with the disappearance of all the main clinical symptoms on the 7
th
 day.