Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

• Published in: European journal of clinical nutrition Vol. 64; no. 4; pp. 400 - 409
• Main Authors: Hosono, S, Matsuo, K, Kajiyama, H, Hirose, K, Suzuki, T, Kawase, T, Kidokoro, K, Nakanishi, T, Hamajima, N, Kikkawa, F, Tajima, K, Tanaka, H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-04-2010; Nature Publishing Group
• Subjects: 631/443/810; 692/699/67/1517/1371; 692/700/459/1994; Adult; Alfacalcidol; Animals; Asian people; Biological and medical sciences; Calcifediol; Calciferol; Calcium; Calcium - deficiency; Calcium, Dietary; Calcium, Dietary - administration & dosage; Cancer; Carcinogenesis; Carcinogens; carcinoma; Case studies; Case-Control Studies; Cervical cancer; Cervical carcinoma; Cervical Intraepithelial Neoplasia - epidemiology; cervical intraepithelial neoplasias grade III; cervical neoplasias; Cervix; Clinical Nutrition; Confidence intervals; Diet; Diet Surveys; Dietary intake; Epidemiology; Feeding. Feeding behavior; Female; Female genital diseases; fish; Fundamental and applied biological sciences. Psychology; green leafy vegetables; Gynecology. Andrology. Obstetrics; Health aspects; Health risks; human diseases; human nutrition; Humans; Internal Medicine; invasive carcinomas; Invasiveness; Japan - epidemiology; Japanese people; Logistic Models; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Milk; nutrient intake; Nutrition research; Odds Ratio; original-article; Prevention; Public Health; Quartiles; Regression analysis; Regression models; Risk; Risk Factors; Seafood; seafoods; Soy Foods; Statistical analysis; Surveys and Questionnaires; Tofu; Tumors; uterine cervical neoplasms; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - prevention & control; Vegetables; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D; Vitamin D - administration & dosage; Vitamin D Deficiency - complications; women; Yogurt; Japan; dietary calcium and vitamin D intake; case–control study; cervical neoplasia; Human; Premalignant lesion; Calcium; Metabolic diseases; Case control study; Inorganic element; Carcinogenesis; Japanese; Female genital diseases; Association; Vitamin D; Food intake; case-control study; Cervical intraepithelial neoplasia; Female; Woman; Uterine cervix diseases
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2010.28

Background/Objectives: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case–control study. Subjects/Methods: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. Results: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63–1.17), 0.50 (95% CI 0.34–0.73) and 0.68 (95% CI 0.48–0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74–1.44; Q3: OR 0.80, 95% CI 0.56–1.15; and Q4: OR 0.64, 95% CI 0.43–0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101). Conclusion: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.