Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018

• Published in: Emerging infectious diseases Vol. 25; no. 7; pp. 1384 - 1388
• Main Authors: Elling, Roland, Böttcher, Sindy, du Bois, Florian, Müller, Alexandra, Prifert, Christiane, Weissbrich, Benedikt, Hofmann, Jörg, Korn, Klaus, Eis-Hübinger, Anna-Maria, Hufnagel, Markus, Panning, Marcus
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01-07-2019; Centers for Disease Control and Prevention
• Subjects: Analysis; Child, Preschool; Cross Infection; Disease Outbreaks; Dispatch; Epidemics; Epidemiology; Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018; Female; Germany - epidemiology; Health aspects; History, 21st Century; Hospitals; Humans; Infant; Infant, Newborn; Infection; Male; Molecular Typing; outbreak; parechovirus; Parechovirus - classification; Parechovirus - genetics; pediatric; Phylogeny; Picornaviridae Infections - diagnosis; Picornaviridae Infections - epidemiology; Picornaviridae Infections - history; Picornaviridae Infections - virology; Polymerase Chain Reaction; RNA, Viral; surveillance; Viral proteins; VP1 sequence; Germany; upsurge; viruses; VP1 sequence; outbreak; phylogeny; surveillance; parechovirus; viral protein 1 sequence; Germany; pediatric
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2507.190257

In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis demonstrated co-circulation of different HPeV-3 sublineages and of HPeV-1 and -5 strains, thereby excluding a nosocomial outbreak. Our findings underline the need for HPeV diagnostics and sequence analysis for outbreak investigations.