Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

• Published in: Science (American Association for the Advancement of Science) Vol. 246; no. 4927; pp. 249 - 251
• Main Authors: Muegge, Kathrin, Williams, Thomas M., Kant, Jeffrey, Karin, Michael, Chiu, Robert, Schmidt, Albrecht, Siebenlist, Ulrich, Young, Howard A., Durum, Scott K.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 13-10-1989; American Association for the Advancement of Science
• Subjects: Animals; AP1 protein; Binding sites; Biology; Cell lines; Cell nucleus; Chloramphenicol O-Acetyltransferase - genetics; DNA binding proteins; Drug receptors; Gels; Gene Expression Regulation; Genes; Genetic transcription; Genetics; HeLa cells; Humans; Interleukin-1; Interleukin-1 - physiology; Interleukin-2; Interleukin-2 - genetics; Laws, regulations and rules; Messenger RNA; Mice; Promoter regions; Promoter Regions, Genetic - genetics; promoters; protein AP-1; Proto-Oncogene Proteins c-jun - genetics; Receptors; T lymphocytes; Tetradecanoylphorbol Acetate - pharmacology; Transcription (Genetics); transcription factors; Transfection; Tumor Cells, Cultured
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2799385

Interleukin-1 (IL-1) is a major regulator of inflammation and immunity. IL-1 induces T lymphocyte growth by acting as a second signal (together with antigen) in enhancing the production of interleukin-2 (IL-2). An IL-1--responsive element in the promoter region of the human IL-2 gene was similar to the binding site for the transcription factor AP-1. IL-1 enhanced expression of c-jun messenger RNA, whereas the antigenic signal enhanced messenger RNA expression of c-fos. Thus, the two components of the AP-1 factor are independently regulated and the AP-1 factor may serve as a nuclear mediator for the many actions of IL-1 on cells.