Light Irradiation Is a Factor in the Bactericidal Activity of Silver-Loaded Zeolite

• Published in: Chemical & Pharmaceutical Bulletin Vol. 56; no. 5; pp. 692 - 694
• Main Authors: Inoue, Yoshihiro, Kogure, Makoto, Matsumoto, Ken-ichiro, Hamashima, Hajime, Tsukada, Masamichi, Endo, Kazutoyo, Tanaka, Tatsuo
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01-05-2008; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - radiation effects; antibacterial activity; Bacteria - drug effects; Bacteria - enzymology; Bacteria - radiation effects; Colony Count, Microbial; Cytochromes c - metabolism; Electron Spin Resonance Spectroscopy; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - radiation effects; Light; light irradiation; Oxygen - chemistry; Oxygen - radiation effects; Reactive Oxygen Species - metabolism; silver; Silver - chemistry; Silver - pharmacology; Silver - radiation effects; Spectrophotometry, Ultraviolet; zeolite; Zeolites - chemistry; Zeolites - pharmacology; Zeolites - radiation effects
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.56.692

Silver loaded zeolite (Ag-Z) was previously found to have effective bactericidal activity against Escherichia coli. To understand the mechanisms of bactericidal activity of Ag-Z, role of light irradiation was focused and investigated in this study. In this study, we focused on light irradiation. Antibacterial assay and spectroscopic study revealed that light irradiation enabled Ag-Z to reduce dioxygen to form a reactive oxygen species, which led to bactericidal activity. These results indicate that the onset of bactericidal activity can be controlled by light irradiation.