Molecular Correlates of Primate Nuclear Transfer Failures

• Published in: Science (American Association for the Advancement of Science) Vol. 300; no. 5617; p. 297
• Main Authors: Simerly, Calvin, Dominko, Tanja, Navara, Christopher, Payne, Christopher, Capuano, Saverio, Gosman, Gabriella, Chong, Kowit-Yu, Takahashi, Diana, Chace, Crista, Compton, Duane, Hewitson, Laura, Schatten, Gerald
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 11-04-2003; The American Association for the Advancement of Science
• Subjects: Aneuploidy; Animals; Biological and medical sciences; Brevia; Cell Division; Cellular biology; Chromosomes; Chromosomes - metabolism; Chromosomes - ultrastructure; Cloning, Organism; Cytology; DNA; Embryo Transfer; Embryo, Mammalian - cytology; Embryology: invertebrates and vertebrates. Teratology; Embryonic stem cells; Embryos; Fertilization in Vitro; Fundamental and applied biological sciences. Psychology; Genetic aspects; Genetic research; Gynecology; Kinesin - metabolism; Macaca mulatta - embryology; Macaca mulatta - genetics; Medical research; Mitotic spindle apparatus; Molecular embryology; Nuclear Proteins - metabolism; Nuclear Transfer Techniques; Oocytes; Oocytes - physiology; Pregnancy; Primates; Reproductive success; Rhesus monkey; Somatic cells; Spindle Apparatus - metabolism; Spindle Apparatus - physiology; Spindle Apparatus - ultrastructure; Stem Cells; Success; Tetraploidy; Animal cloning; Primates; Transfer; Vertebrata; Mammalia; Cell nucleus
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1082091

Somatic cell nuclear transfer in nonhuman primates could accelerate medical research by contributing identical animals for research and clarifying embryonic stem cell potentials. Although rhesus embryos begin development after embryonic cell nuclear transfer, there has only been one report of rhesus births after ECNT and that report has not been replicated.