First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells

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Bibliographic Details
Published in:	Leukemia Vol. 32; no. 10; pp. 2291 - 2295
Main Authors:	Hojjat-Farsangi, M., Daneshmanesh, A. H., Khan, A. S., Shetye, J., Mozaffari, F., Kharaziha, P., Rathje, L.-S., Kokhaei, P., Hansson, L., Vågberg, J., Byström, S., Olsson, E., Löfberg, C., Norström, C., Schultz, J., Norin, M., Olin, T., Österborg, A., Mellstedt, H., Moshfegh, A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-10-2018 Nature Publishing Group
Subjects:	13 13/2 13/31 13/51 14 14/63 38/47 38/79 45/61 631/67/1059/153 64/60 692/699/67/1059/153 82/29 82/47 82/51 96/1 96/106 Acute myelocytic leukemia Apoptosis Apoptosis - drug effects B cells Brief Communication Cancer cells Cancer Research Cell Line, Tumor Cellular signal transduction Chronic lymphocytic leukemia Critical Care Medicine Enzyme inhibitors Genetic aspects Hematology Humans Intensive Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Lymphatic leukemia Lymphocytic leukemia Medicin och hälsovetenskap Medicine Medicine & Public Health Oncology Phenols (Class of compounds) Prognosis Protein-tyrosine kinase Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors Signal Transduction - drug effects Small Molecule Libraries - therapeutic use Tyrosine Universities and colleges
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Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0887-6924 1476-5551 1476-5551
DOI:	10.1038/s41375-018-0113-1