Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
The microenvironment has a central role in tumor promotion. Here Mina Bissell and William C. Hines discuss how the normal tissue architecture may substantially suppress tumor development and how loss of normal tissue homeostasis results in an aberrant microenvironment that is conducive to tumor deve...
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Published in: | Nature medicine Vol. 17; no. 3; pp. 320 - 329 |
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Main Authors: | , |
Format: | Journal Article |
Language: | English |
Published: |
New York
Nature Publishing Group US
01-03-2011
Nature Publishing Group |
Subjects: | |
Online Access: | Get full text |
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Summary: | The microenvironment has a central role in tumor promotion. Here Mina Bissell and William C. Hines discuss how the normal tissue architecture may substantially suppress tumor development and how loss of normal tissue homeostasis results in an aberrant microenvironment that is conducive to tumor development.
Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 |
ISSN: | 1078-8956 1546-170X |
DOI: | 10.1038/nm.2328 |