Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

• Published in: Neural regeneration research Vol. 16; no. 1; pp. 6 - 11
• Main Authors: Zhang, Wan, Tian, Tian, Gong, Shao-Xin, Huang, Wen-Qian, Zhou, Qin-Yi, Wang, Ai-Ping, Tian, Ying
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01-01-2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Institute of Clinical Research,Affiliated Nanhua Hospital,University of South China,Hengyang,Hunan Province,China%Department of Clinical Laboratory,the First Hospital of Changsha,Changsha,Hunan Province,China%Department of Pathology,the First Affiliated Hospital of University of South China,Hengyang,Hunan Province,China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: brain; cells; central nervous system; inflammation; injury; macrophages; repair; review; stroke; Care and treatment; Development and progression; Diuretics; Health aspects; Inflammation; Microglia; Physiological aspects; Review; Stroke; Transient ischemic attack; China; repair; macrophages; cells; inflammation; review; injury; brain; stroke; central nervous system
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.286954

Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, there is no effective strategy for treating ischemic stroke in clinical practice. Therefore, it is clinically important to study the role and regulation of microglia in stroke. In this review, we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke, with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.