A cutaneous mixed tumor in a dog

• Published in: Journal of Veterinary Medical Science Vol. 79; no. 3; pp. 670 - 673
• Main Authors: WATANABE, Ken-ichi, CHAMBERS, James K., UCHIDA, Kazuyuki, NIBE, Kazumi, USHIO, Nanako, HORIUCHI, Noriyuki, KOBAYASHI, Yoshiyasu, NAKAYAMA, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2017; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; CD34 antigen; Cell proliferation; cutaneous mixed tumor; Cytokeratin; Cytoplasm; dog; Dog Diseases - pathology; Dogs; Female; Follicles; Glands; hair follicle; Metaplasia; Mixed Tumor, Malignant - pathology; Mixed Tumor, Malignant - veterinary; multiphenotypic differentiation; Pathology; Skin Neoplasms - pathology; Skin Neoplasms - veterinary
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.16-0610

The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neoplastic cells in trichoblastic area were also positive for cytokeratin 15 and CD34. Neoplastic cells in apocrine glandular area were positive for pan-cytokeratin and cytokeratin 7, 18 and 19. Myoepithelial cell proliferation with osteocartilaginous metaplasia was observed in this area. Since neoplastic cells showed multiphenotypic differentiation for hair follicles and apocrine glands, the present case was diagnosed as a cutaneous mixed tumor.