Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk

• Published in: Acta diabetologica Vol. 45; no. 4; pp. 231 - 235
• Main Authors: Resic-Lindehammer, Sabina, Larsson, K., Örtqvist, E., Carlsson, A., Cederwall, E., Cilio, C. M., Ivarsson, S.-A., Jönsson, B. A., Larsson, H. E., Lynch, K., Neiderud, J., Nilsson, A., Sjöblad, S., Lernmark, Å.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 2008; Springer Nature B.V
• Subjects: Adolescent; Age at diagnosis; Age of Onset; Autoimmune disease; Child; Child, Preschool; Clinical Medicine; Comparative studies; Dermatologi och venerologi, klinisk genetik, invärtesmedicin; Dermatology and venerology,clinical genetics, internal medicine; Diabetes; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetologi; Diabetology; Endocrinology and Diabetes; Endokrinologi och diabetes; Female; Gene Frequency; Genotype; Genotype & phenotype; HLA Antigens - genetics; HLA-DQ; HLA-DQ alpha-Chains; HLA-DQ Antigens - genetics; HLA-DQ beta-Chains; Humans; Infant; Internal Medicine; Invärtesmedicin; Klinisk medicin; Male; MEDICAL AND HEALTH SCIENCES; MEDICIN; MEDICIN OCH HÄLSOVETENSKAP; MEDICINE; Medicine & Public Health; Metabolic Diseases; Original Article; Pediatrics; Risk factors; Sweden - epidemiology; Temporal trends; Trends; Sweden; Temporal trends; Genotype; Autoimmune disease; Age at diagnosis; HLA-DQ
• ISSN: 0940-5429; 1432-5233; 1432-5233
• DOI: 10.1007/s00592-008-0048-5

The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1–18-year-old patients with type 1 diabetes newly diagnosed in 1986–1987 (
n
 = 430), 1996–2000 (
n
 = 342) and in 2003–2005 (
n
 = 171). We tested the hypothesis that the
HLA DQ
genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for
DQ A1
* and
B1
* alleles. The most common type 1 diabetes HLA
DQA1*-B1*
genotype
0501-0201/0301-0302
was 36% (153/430) in 1986–1987 and 37% (127/342) in 1996–2000, but decreased to 19% (33/171) in 2003–2005 (
P
 < 0.0001). The
0501-0201/0501-0201
genotype increased from 1% in 1986–1987 to 7% in 1996–2000 (
P
 = 0.0047) and to 5% in 2003–2005 (
P
 > 0.05). This study in 1–18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.