Copeptin is independently associated with vascular calcification in chronic kidney disease stage 5

• Published in: BMC nephrology Vol. 21; no. 1; p. 43
• Main Authors: Golembiewska, Edyta, Qureshi, Abdul Rashid, Dai, Lu, Lindholm, Bengt, Heimbürger, Olof, Söderberg, Magnus, Brismar, Torkel B, Ripsweden, Jonaz, Barany, Peter, Johnson, Richard J, Stenvinkel, Peter
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07-02-2020; BioMed Central; BMC
• Subjects: Analysis; Argipressin; Arteriosclerosis; Atherosclerosis; Biological markers; Blood pressure; Calcification; Calcification (ectopic); Cardiovascular diseases; Cholesterol; Chronic kidney disease; Chronic kidney failure; Computed tomography; Copeptin; Coronary artery; Coronary vessels; Development and progression; Diabetes; Diabetes mellitus; End-stage renal disease; Etiology; Fibroblasts; Growth factors; Hemodialysis; Hypertension; Kidney diseases; Kidney transplantation; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Metabolism; Nephrology; Peptides; Peritoneal dialysis; Peritoneum; Phosphatase; Physiological aspects; Risk factors; Triglycerides; Tumor necrosis factor-TNF; Vascular calcification; Vasopressin; Veins & arteries; Sweden; United States > US; Vascular calcification; End-stage renal disease; Chronic kidney disease; Copeptin
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-020-1710-6

Vascular calcification (VC) is an independent predictor of cardiovascular disease (CVD) present in 30-70% of patients with chronic kidney disease (CKD). Copeptin is a sensitive surrogate marker of arginine vasopressin (AVP), which is involved in many pathophysiologic processes in CKD. The aim of the present study was to explore the association of copeptin with VC in CKD stage 5.
Copeptin was investigated in conjunction with living donor kidney transplantation in 149 clinically stable CKD stage 5 patients (CKD5), including 53 non-dialyzed (CKD5-ND) and 96 dialysis patients treated by peritoneal dialysis (PD) (n = 43) or hemodialysis (HD) (n = 53). We analyzed the association of copeptin with presence and extent of VC ascertained both histologically in biopsies from the inferior epigastric artery (n = 137) and by coronary artery calcification (CAC) score measured by computed tomography.
Patients with higher copeptin were older, had higher systolic blood pressure, higher prevalence of CVD and their preceding time on chronic dialysis was longer. In Spearman's rank correlations (Rho), copeptin concentrations were significantly associated with CAC score (Rho = 0.27; p = 0.003) and presence of medial VC (Rho = 0.21; p = 0.016). Multivariate logistic regression analysis showed that 1-SD higher age, male gender, diabetes and 1-SD higher copeptin were significantly associated with the presence of moderate-extensive VC.
High circulating levels of copeptin in CKD5 patients are independently associated with the degree of medial calcification ascertained by histology of arterial biopsies. Thus, plasma copeptin may serve as a marker of the uremic calcification process.