Fusarium: Molecular Diversity and Intrinsic Drug Resistance

• Published in: PLoS pathogens Vol. 12; no. 4; p. e1005464
• Main Authors: Al-Hatmi, Abdullah M S, Meis, Jacques F, de Hoog, G Sybren
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01-04-2016; Public Library of Science (PLoS)
• Subjects: 19th century; Analysis; Animals; Antifungal Agents - pharmacology; Biology and Life Sciences; Clinical trials; Crop diseases; Cytotoxicity; Drug resistance; Drug Resistance - genetics; Fusarium; Fusarium - drug effects; Fusarium - isolation & purification; Genetic Variation - genetics; Health aspects; Hospitals; Humans; Infections; Medicine and Health Sciences; Microbial drug resistance; Morphology; Mortality; Pathogens; Pearls; Physical Sciences; Plant Diseases - microbiology; Prevalence; Studies; Testing; Voriconazole
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1005464

After 1960, the increasing use of antibiotics became a major predisposing condition [4]. Since 1970, prolonged neutropenia due to intensified cytotoxic treatment of hematologic malignancies was the leading risk factor in novel types of fusariosis [5]. Since 1980, Fusarium infections have been seen in severely immunocompromised patients with a 100% mortality rate, e.g., in cases of cerebral involvement [6]. To date, about 36 of the alleged human opportunists carry a name, while 38 are still unnamed and can only be identified by multilocus sequence analysis (MLSA). [...]far, 21 species have been described with proven case reports [16], and more have been published in the literature.