Origins and evolution of the Europeans' genome: evidence from multiple microsatellite loci

• Published in: Proceedings of the Royal Society. B, Biological sciences Vol. 273; no. 1594; pp. 1595 - 1602
• Main Authors: Belle, Elise M.S, Landry, Pierre-Alexandre, Barbujani, Guido
• Format: Journal Article
• Language: English
• Published: London The Royal Society 07-07-2006
• Subjects: Admixture; Admixtures; Clines; Demic Diffusion; DNA; Estimation methods; Europe; Evolution; Evolution, Molecular; Evolutionary genetics; Gene Flow; Genetic Drift; Genetic loci; Genome Diversity; Genome, Human; Genomes; Human; Human genetics; Humans; Microsatellite Repeats; Polymorphism, Genetic; Population genetics; Short Tandem Repeat Polymorphisms; Tandem Repeat Sequences; Europe
• ISSN: 0962-8452; 1471-2954
• DOI: 10.1098/rspb.2006.3494

There is general agreement that the current European gene pool is mainly derived from Palaeolithic hunting-gathering and Neolithic farming ancestors, but different studies disagree on the relative weight of these contributions. We estimated admixture rates in European populations from data on 377 autosomal microsatellite loci in 235 individuals, using five different numerical methods. On average, the Near Eastern (and presumably Neolithic) contribution was between 46 and 66%, and admixture estimates showed, with all methods, a strong and significant negative correlation with distance from the Near East. If the assumptions of the model are approximately correct, i.e. if the Basques' and Near Easterners' genomes represent a good approximation to the Palaeolithic and Neolithic settlers of Europe, respectively, these results imply that half or more of the Europeans' genes are descended from Near Eastern ancestors who immigrated in Europe 10 000 years ago. If these assumptions are incorrect, our results show anyway that clinal variation is the rule in the Europeans' genomes and that lower estimates of Near Eastern admixture obtained from the analysis of single markers do not reflect the patterns observed at the genomic level.