Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity

• Published in: PloS one Vol. 13; no. 4; p. e0196111
• Main Authors: Morillas-de-Laguno, Pablo, Vargas-Hitos, José A, Rosales-Castillo, Antonio, Sáez-Urán, Luis Manuel, Montalbán-Méndez, Cristina, Gavilán-Carrera, Blanca, Navarro-Mateos, Carmen, Acosta-Manzano, Pedro, Delgado-Fernández, Manuel, Sabio, José M, Ortego-Centeno, Norberto, Callejas-Rubio, José L, Soriano-Maldonado, Alberto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25-04-2018; Public Library of Science (PLoS)
• Subjects: Accelerometers; Accelerometry; Adult; Analysis; Arthritis; Atherosclerosis; Autoimmune diseases; Behavior; Biology and Life Sciences; Blood pressure; Care and treatment; Castillo, Luis; Chronic conditions; Cross-Sectional Studies; Engineering and Technology; Exercise; Exercise - physiology; Female; Guidelines; Hospitals; Humans; Hypertension; Internal medicine; Life assessment; Lupus; Lupus Erythematosus, Systemic - physiopathology; Medicine; Medicine and Health Sciences; Metabolism; Middle Aged; Mortality; Nutrition; Patients; Physical activity; Physical education; Physical fitness; Physical Sciences; Population; Prospective Studies; Public health; Pulse Wave Analysis; Sedentary Behavior; Severity of Illness Index; Stiffness; Systemic lupus erythematosus; Type 2 diabetes; Vascular Stiffness; Velocity; Wave analysis; Wave velocity; Womens health; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0196111

To examine the association of objectively measured physical activity (PA) intensity levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus (SLE) with mild disease activity and to analyze whether participants meeting the international PA guidelines have lower arterial stiffness than those not meeting the PA guidelines.
The study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9]) years, with clinical and treatment stability during the 6 months prior to the study. PA intensity levels and sedentary time were objectively measured with triaxial accelerometry. Arterial stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph® 24h pulse wave analysis monitor.
The average time in moderate to vigorous PA in bouts of ≥10 consecutive minutes was 135.1±151.8 minutes per week. There was no association of PA intensity levels and sedentary time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280).
Our results suggest that PA intensity levels and sedentary time are not associated with arterial stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting international PA guidelines did not present lower arterial stiffness than those not meeting the PA guidelines. Future prospective research is needed to better understand the association of PA and sedentary time with arterial stiffness in patients with SLE.