Escalating spread of SARS-CoV-2 infection after school reopening among students in hotspot districts of Oromia Region in Ethiopia: Longitudinal study

• Published in: PloS one Vol. 18; no. 2; p. e0280801
• Main Authors: Gobena, Dabesa, Kebede Gudina, Esayas, Yilma, Daniel, Girma, Tsinuel, Gebre, Getu, Gelanew, Tesfaye, Abdissa, Alemseged, Mulleta, Daba, Sarbessa, Tarekegn, Asefa, Henok, Woldie, Mirkuzie, Shumi, Gemechu, Kenate, Birhanu, Kroidl, Arne, Wieser, Andreas, Eshetu, Beza, Degfie, Tizta Tilahun, Mekonnen, Zeleke
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03-02-2023; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and life sciences; Child; Coronaviruses; COVID-19; COVID-19 - epidemiology; Disease hot spots; Disease transmission; Earth Sciences; Electronic components industry; Elementary school students; Epidemics; Epidemiology; Ethiopia; Ethiopia - epidemiology; Family size; Health aspects; High schools; Hot spots; Humans; Infection; Infections; International economic relations; Longitudinal Studies; Medicine and Health Sciences; Nucleocapsids; Outbreaks; Pandemics; People and Places; Prospective Studies; SARS-CoV-2; Schools; Seroepidemiologic Studies; Seroepidemiology; Serology; Severe acute respiratory syndrome coronavirus 2; Social Sciences; Students; Sub-Saharan Africa; United States; Viral diseases; Ethiopia; United States; Sub-Saharan Africa
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0280801

COVID-19 pandemic caused by extended variants of SARS-CoV-2 has infected more than 350 million people, resulting in over 5.5 million deaths globally. However, the actual burden of the pandemic in Africa, particularly among children, remains largely unknown. We aimed to assess the seroepidemiological changes of SARS-CoV-2 infection after school reopening among school children in Oromia, Ethiopia.
A prospective cohort study involving students aged 10 years and older were used. A serological survey was performed twice, at school reopening in December 2020 and four months later in April 2021. Participants were selected from 60 schools located in 15 COVID-19 hotspot districts in Oromia Region. Serology tests were performed by Elecsys anti-SARS-CoV-2 nucleocapsid assay. Data were collected using CSentry CSProData Entry 7.2.1 and exported to STATA version 14.2 for data cleaning and analysis.
A total of 1884 students were recruited at baseline, and 1271 completed the follow-up. SARS-CoV-2 seroprevalence almost doubled in four months from 25.7% at baseline to 46.3% in the second round, with a corresponding seroincidence of 1910 per 100,000 person-week. Seroincidence was found to be higher among secondary school students (grade 9-12) compared to primary school students (grade 4-8) (RR = 1.6, 95% CI 1.21-2.22) and among those with large family size (> = 5) than those with a family size of <3 (RR = 2.1, 95% CI 1.09-4.17). The increase in SARS-CoV-2 seroprevalence among the students corresponded with Ethiopia's second wave of the COVID-19 outbreak.
SARS-CoV-2 seroprevalence among students in hotspot districts of the Oromia Region was high even at baseline and almost doubled within four months of school recommencement. The high seroincidence coincided with the second wave of the COVID-19 outbreak in Ethiopia, indicating a possible contribution to school opening for the new outbreak wave.