LAMP: A Database Linking Antimicrobial Peptides

The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 6; p. e66557
Main Authors:	Zhao, Xiaowei, Wu, Hongyu, Lu, Hairong, Li, Guodong, Huang, Qingshan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18-06-2013 Public Library of Science (PLoS)
Subjects:	Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial Cationic Peptides - chemistry Antimicrobial peptides Bacteria Bioinformatics Biology Clinical trials Combinatorial analysis Crosslinking Cytotoxicity Data bases Databases, Protein Drug resistance Drugs Genetic engineering Humans Hyperlinks Internet Laboratories Life sciences Medical research Medicine Peptides Proteins R&D Research & development Researchers Studies Synthetic peptides Toxicity User-Computer Interface China
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Summary:	The frequent emergence of drug-resistant bacteria has created an urgent demand for new antimicrobial agents. Traditional methods of novel antibiotic development are almost obsolete. Antimicrobial peptides (AMPs) are now regarded as a potential solution to revive the traditional methods of antibiotic development, although, until now, many AMPs have failed in clinical trials. A comprehensive database of AMPs with information about their antimicrobial activity and cytotoxicity will help promote the process of finding novel AMPs with improved antimicrobial activity and reduced cytotoxicity and eventually accelerate the speed of translating the discovery of new AMPs into clinical or preclinical trials. LAMP, a database linking AMPs, serves as a tool to aid the discovery and design of AMPs as new antimicrobial agents. The current version of LAMP has 5,547 entries, comprising 3,904 natural AMPs and 1,643 synthetic peptides. The database can be queried using either simply keywords or combinatorial conditions searches. Equipped with the detailed antimicrobial activity and cytotoxicity data, the cross-linking and top similar AMPs functions implemented in LAMP will help enhance our current understanding of AMPs and this may speed up the development of new AMPs for medical applications. LAMP is freely available at: http://biotechlab.fudan.edu.cn/database/lamp.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: Shanghai High-Tech Bioengineering Co., Ltd (SHB) and Shanghai High-Tech United Bio-Technological R&D Co. Ltd (SHUB) are independent member companies of Yingtai Group, which is dedicated to researching, producing and selling products related to bio-disinfectant. Xiaowei Zhao is affiliated SHB and currently major in Master of Engineering at the State Key Laboratory of Genetic Engineering (SKLGE) at Fudan University. The program of Master of Engineering in China set two mentors from University and Industry respectively. Her two mentors are Guodong Li and Qingshan Huang, from SHUB and SKLGE separately. Hongyu Wu is affiliated SHUB as a paid employee. Hairong Lu is affiliated SHUB as a paid employee and currently major in Genetics as a PhD student at SKLGE. Guodong Li is the CTO at SHUB. Qingshan Huang is affiliated Fudan University and as a paid consultant at SHUB. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Conceived and designed the experiments: GL QH. Performed the experiments: XZ HW. Analyzed the data: XZ HW HL. Contributed reagents/materials/analysis tools: XZ HW HL. Wrote the paper: XZ HW.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0066557