Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families

• Published in: PloS one Vol. 7; no. 12; p. e52262
• Main Authors: Gadelha, Ary, Ota, Vanessa Kiyomi, Cano, Jose Paya, Melaragno, Maria Isabel, Smith, Marilia A C, de Jesus Mari, Jair, Bressan, Rodrigo A, Belangero, Sintia Iole, Breen, Gerome
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31-12-2012; Public Library of Science (PLoS)
• Subjects: Adolescent; Autism; Biology; Bipolar disorder; Brazil; Chromosomes; Chromosomes, Human, Pair 13 - genetics; Empirical analysis; Female; Genes; Genetic Linkage - genetics; Genetics; Genomes; Genomics; Humans; Interdisciplinary aspects; Male; Medical records; Medical research; Medicine; Mental depression; Mental disorders; Meta-analysis; Morphology; Neurosciences; Pedigree; Pilot Projects; Psychiatry; Psychosis; Schizophrenia; Schizophrenia - genetics; Statistics, Nonparametric; Studies; Young Adult; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0052262

We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.