ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population

• Published in: PloS one Vol. 14; no. 3; p. e0214080
• Main Authors: Macías-Gómez, Nelly Margarita, Hernández-Terrones, María Carmen, Ramírez-Guerrero, Angélica Araceli, Leal-Ugarte, Evelia, Gutiérrez-Angulo, Melva, Peregrina-Sandoval, Jorge
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18-03-2019; Public Library of Science (PLoS)
• Subjects: Adiponectin; Adiponectin - genetics; Adiponectin - metabolism; Adult; Analysis; Anthropometry; Anti-inflammatory agents; Apoptosis; Biochemical markers; Biochemistry; Biological markers; Biology and Life Sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Blood Glucose - metabolism; Body fat; Body mass; Body mass index; Body size; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - genetics; Cancer; Cancer research; Carcinoma, Ductal, Breast - blood; Carcinoma, Ductal, Breast - genetics; Carriers; Chemotherapy; Cholesterol; Cross-Sectional Studies; Diabetes; Female; Gene frequency; Gene polymorphism; Genes; Genetic aspects; Genotypes; Glucose; Glucose metabolism; Health risk assessment; Hip; Humans; Inflammation; Lipid metabolism; Lipids; Low density lipoproteins; Male; Markers; Medical research; Medicine and Health Sciences; Metabolism; Mexico; Middle Aged; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Patients; People and places; Physical Sciences; Physiological aspects; Polymerase chain reaction; Polymorphism; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Population studies; Proteins; Restriction fragment length polymorphism; Risk analysis; Risk factors; Single-nucleotide polymorphism; Triglycerides; Tumors; Women; Women's health; Womens health; Mexico
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0214080

Adiponectin protein and some variations in its gene, ADIPOQ have recently been associated with cancer because they regulate glucose and lipid metabolism as well as anti-apoptotic and anti-inflammatory proteins.
The aim of this study was to analyse the relationship between selected biochemical markers, anthropometric indices and ADIPOQ rs2241766 and rs1501299 SNPs in ductal infiltrating breast cancer (DIBC) in a Mexican population.
This cross-sectional study included 64 DIBC patients and 167 healthy women. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to identify the genotypes of the rs2241766 (exon 2) and rs1501299 (intron 2) ADIPOQ polymorphisms. Corporal composition and biochemical markers included body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), glucose, cholesterol, triglycerides and high- and low-density lipoprotein cholesterol.
Patients with DIBC had higher serum glucose, WC and WHR than controls. Intergroup differences in allele and genotype frequencies were found for both polymorphisms (P < 0.05). Patients carrying the rs2241766 TT and TG genotypes had higher values of WC, HC and WHR, but only TG carriers had higher levels of glucose. For the SNP rs1501299, carriers of the GG genotype in the DIBC group had higher values of glucose, WC, HC and WHR than the respective control group.
These results suggest that WC, HC and WHR are better predictors of DIBC than BMI. The ADIPOQ SNP rs2241766 emerges as a protective factor, whereas rs1501299 is a risk factor for DIBC development in a Mexican population.