Metabolic and inflammatory links to rotator cuff tear in hand osteoarthritis: A cross sectional study

• Published in: PloS one Vol. 15; no. 2; p. e0228779
• Main Authors: Suh, Young Sun, Kim, Hyun-Ok, Cheon, Yun-Hong, Kim, Mingyo, Kim, Rock-Bum, Park, Ki-Soo, Park, Hyung Bin, Na, Jae-Beom, Moon, Jin Il, Lee, Sang-Il
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10-02-2020; Public Library of Science (PLoS)
• Subjects: Agreements; Arthritis; Biology and Life Sciences; Biomedical materials; Blood tests; Bone surgery; C-reactive protein; Cholesterol; Confidence intervals; Cross-Sectional Studies; Female; Hand Joints; Hands; Health sciences; High density lipoprotein; Hospitals; Humans; Inflammation; Inflammation - complications; Internal medicine; Lipoproteins (high density); Magnetic resonance; Magnetic resonance imaging; Male; Medicine and Health Sciences; Metabolism; Middle Aged; Osteoarthritis; Osteoarthritis - complications; Pain; Prevalence; Preventive medicine; Questionnaires; Radiography; Radiology; Regression analysis; Research and Analysis Methods; Rheumatology; Rotator cuff; Rotator Cuff Injuries - complications; Rotator Cuff Injuries - metabolism; Rural areas; Serum levels; Statistical analysis; Studies; South Korea; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0228779

To estimate the prevalence and associated factors of rotator cuff tear (RCT) in patients with hand osteoarthritis (HOA).
Between June 2013 and December 2015, we recruited 1150 participants in rural area of South Korea. Of the 1150 participants, 307 participants with HOA were analyzed. Plain radiography of both hands, magnetic resonance imaging of both shoulders, and serum levels of high-sensitive C-reactive protein (hsCRP) and high-density lipoprotein (HDL) were obtained for all patients. HOA and RCT were diagnosed by clinical and radiologic findings.
The prevalence of RCT in patients with HOA (192/307, 62.5%) was higher than that in those without HOA (410/827, 49.5%, p<0.001). Among the 307 patients with HOA, the patients with RCT were older, and had higher hsCRP and lower HDL levels than the patients without RCT. Multiple logistic regression analysis confirmed significant associations of age (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02-1.11), serum hsCRP levels ≥0.6mg/L (OR, 1.68; CI, 1.00-2.80), and low HDL levels (male, <50 mg/dL; female, <40 mg/dL) (OR, 1.93; CI, 1.05-3.56) with RCT in patients with HOA. For patients below 60 years old, the prevalence of RCT was 2.8-fold higher in the low HDL group than normal HDL group (p = 0.048). Finally, the prevalence of RCT was 2.6-fold higher in patients with HOA with both elevated hsCRP and low HDL levels compared with those with neither (p<0.05).
Our findings suggest inflammation and metabolic factors were associated with the prevalence of RCT in HOA patients.