Safety and data quality of EEG recorded simultaneously with multi-band fMRI

• Published in: PloS one Vol. 16; no. 7; p. e0238485
• Main Authors: Egan, Maximillian K, Larsen, Ryan, Wirsich, Jonathan, Sutton, Brad P, Sadaghiani, Sepideh
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02-07-2021; Public Library of Science (PLoS)
• Subjects: Adult; Biology and Life Sciences; Brain - diagnostic imaging; Brain - physiology; Brain mapping; Data Accuracy; Data security; EEG; Electrodes; Electroencephalography; Electroencephalography - methods; Engineering and Technology; Evaluation; Female; Functional magnetic resonance imaging; Heating; Humans; Information management; Magnetic fields; Magnetic resonance; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Management; Medical records; Medicine and Health Sciences; Methods; Neuroimaging; Phantoms, Imaging; Physical Sciences; Quality assessment; Radio frequency; Research and Analysis Methods; Safety; Social Sciences; Subtraction; Young Adult; United States; United States > US; Illinois
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0238485

Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about EEG data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we measure the relative heating of a MB protocol compared with a standard single-band (SB) protocol considered to be safe. We also evaluated EEG quality recorded concurrently with the MB protocol on humans.
We compared radiofrequency (RF)-related heating at multiple electrodes and magnetic field magnitude, B1+RMS, of a MB fMRI sequence with whole-brain coverage (TR = 440 ms, MB factor = 4) against a previously recommended, safe SB sequence using a phantom outfitted with a 64-channel EEG cap. Next, 9 human subjects underwent eyes-closed resting state EEG-fMRI using the MB sequence. Additionally, in three of the subjects resting state EEG was recorded also during the SB sequence and in an fMRI-free condition to directly compare EEG data quality across scanning conditions. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts along with a clean spectrogram.
The heating induced by the MB sequence was lower than that of the SB sequence by a factor of 0.73 ± 0.38. This is consistent with an expected heating ratio of 0.64, calculated from the square of the ratio of B1+RMS values of the sequences. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. The success of artifact rejection for the MB sequence was comparable to that in traditional SB sequences.
Our study shows that B1+RMS is a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality after traditional artifact removal techniques.