Risk factors for hydrocephalus following fourth ventricle tumor surgery: A retrospective analysis of 121 patients

• Published in: PloS one Vol. 15; no. 11; p. e0241853
• Main Authors: Chen, Tengyun, Ren, Yanming, Wang, Chenghong, Huang, Bowen, Lan, Zhigang, Liu, Wenke, Ju, Yan, Hui, Xuhui, Zhang, Yuekang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17-11-2020; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Biology and Life Sciences; Brain tumors; Care and treatment; Cerebral Ventricle Neoplasms - complications; Cerebral Ventricle Neoplasms - diagnostic imaging; Cerebral Ventricle Neoplasms - surgery; Cerebrospinal fluid; Cerebrospinal Fluid Shunts - methods; Child; Child, Preschool; Complications and side effects; Drainage; Female; Fourth Ventricle - pathology; Fourth Ventricle - surgery; Headaches; Histology; Humans; Hydrocephalus; Hydrocephalus - diagnostic imaging; Hydrocephalus - etiology; Hydrocephalus - prevention & control; Magnetic resonance imaging; Male; Medicine and Health Sciences; Multivariate analysis; Neurosurgery; Neurosurgical Procedures - adverse effects; Patients; Postoperative complications; Postoperative Complications - epidemiology; Postoperative Complications - therapy; Retrospective Studies; Risk analysis; Risk Factors; Surgery; Surgical drains; Tumor Burden; Tumor removal; Tumors; Ventricle; Ventricles (cerebral); Vomiting; Wound drainage; Young Adult; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0241853

Most patients who present with a fourth ventricle tumor have concurrent hydrocephalus, and some demonstrate persistent hydrocephalus after tumor resection. There is still no consensus on the management of hydrocephalus in patients with fourth ventricle tumor after surgery. The purpose of this study was to identify the factors that predispose to postoperative hydrocephalus and the need for a postoperative cerebrospinal fluid (CSF) diversion procedure.
We performed a retrospective analysis of patients who underwent surgery of the fourth ventricle tumor between January 2013 and December 2018 at the Department of Neurosurgery in West China Hospital of Sichuan University. The characteristics of patients and the tumor location, tumor size, tumor histology, and preventive external ventricular drainage (EVD) that were potentially correlated with CSF circulation were evaluated in univariate and multivariate analysis.
A total of 121 patients were enrolled in our study; 16 (12.9%) patients underwent postoperative CSF drainage. Univariate analysis revealed that superior extension (p = 0.004), preoperative hydrocephalus (p<0.001), and subtotal resection (p<0.001) were significantly associated with postoperative hydrocephalus. Multivariate analysis revealed that superior extension (p = 0.013; OR = 44.761; 95% CI 2.235-896.310) and subtotal resection (p = 0.005; OR = 0.087; 95% CI 0.016-0.473) were independent risk factors for postoperative hydrocephalus after resection of fourth ventricle tumor.
Superior tumor extension (into the aqueduct) and failed total resection of tumor were identified as independent risk factors for postoperative hydrocephalus in patients with fourth ventricle tumor.