HLA class I and class II associations with ESRD in Saudi Arabian population

• Published in: PloS one Vol. 9; no. 11; p. e111403
• Main Authors: Hamdi, Nuha Mahmoud, Al-Hababi, Fadel Hassan, Eid, Amr Ekhlas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07-11-2014; Public Library of Science (PLoS)
• Subjects: Adult; Alleles; Antigens; Biology and Life Sciences; Case-Control Studies; Chronic kidney failure; Deoxyribonucleic acid; Diabetes; DNA; Drb1 protein; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Hemodialysis; Histocompatibility antigen HLA; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class II - genetics; HLA antigens; Humans; Hypertension; Immunology; Kidney diseases; Kidney Failure, Chronic - genetics; Kidney transplantation; Laboratories; Male; Medicine and Health Sciences; Nephrology; Patients; Polymorphism, Genetic; Population; Population (statistical); Population studies; Renal failure; Renal replacement therapy; Retrospective Studies; Saudi Arabia; Statistical correlation; Transplants & implants; Tumor necrosis factor-TNF; Saudi Arabia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0111403

Chronic renal failure (CRF) leads in the majority of instances to end stage renal disease (ESRD) requiring renal replacement therapy. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population.
A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated control. Patients and control groups were typed by SSOP lumenix techniques. The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50. The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03. The negatively associated haplotypes were: HLA-A*02-B*39, A*02-B*50, A*24-B*35, A*24-B*58, A*24-DRB1*16, A*68-DRB1*04, A*02-DQB1*03, A*29-DQB1*02, A*29-DOB1*05 and B*27-DRB1*07 and the last one is the most significant protective haplotypes.
The high Relative Risk (RR) observed and its statistical correlation reflect the strength of the described association between HLA antigens and ESRD.