Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

• Published in: Chemical & Pharmaceutical Bulletin Vol. 56; no. 8; pp. 1181 - 1183
• Main Authors: Nishide, Midori, Yoshikawa, Yutaka, Yoshikawa, Eriko U., Matsumoto, Kinuyo, Sakurai, Hiromu, KAJIWARA, Naemi M.
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01-08-2008; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Adipocytes - drug effects; Adipocytes - metabolism; Animals; Fatty Acids, Nonesterified - metabolism; Glucose - metabolism; glucose-uptake activity; Hypoglycemic Agents - pharmacology; inhibition of free fatty acid-release; Insulin - chemistry; insulinomimetic activity; Rats; Zinc - chemistry; Zinc - pharmacology; Zn(II) complex
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.56.1181

We prepared 4 new Zn(II) complexes with Zn(O4), Zn(N2O2), and Zn(S2O2) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)2), bis(α-furonic acidato)zinc (Zn(fa)2), bis(thiophene-2-carboxylato)zinc (Zn(tc)2), and bis(thiophene-2-acetato)zinc (Zn(ta)2) complexes were found to be higher than that of zinc sulfate (ZnSO4). Zn(ta)2 showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.