Infectivity of Norovirus GI and GII from Bottled Mineral Water during a Waterborne Outbreak, Spain

• Published in: Emerging infectious diseases Vol. 26; no. 1; pp. 134 - 137
• Main Authors: Guix, Susana, Fuentes, Cristina, Pintó, Rosa M, Blanco, Albert, Sabrià, Aurora, Anfruns-Estrada, Eduard, Garrido, Virginia Rodríguez, Alonso, Manuel, Bartolomé, Rosa, Cornejo, Thais, Pumarola, Tomàs, Bosch, Albert
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01-01-2020; Centers for Disease Control and Prevention
• Subjects: 50% illness dose; Adult; Antigens; Bottled drinking water; Caliciviridae Infections - epidemiology; Caliciviridae Infections - etiology; Caliciviridae Infections - virology; Disease Outbreaks; Disease susceptibility; Diseases; Dispatch; Estimates; Food contamination & poisoning; Gastroenteritis; Gastroenteritis - epidemiology; Gastroenteritis - etiology; Gastroenteritis - virology; Genes; Genetic aspects; Genomes; Genomics; Genotypes; GII; Health aspects; Humans; Infection; Infections; infectivity; Infectivity of Norovirus GI and GII from Bottled Mineral Water during Waterborne Outbreak, Spain; Medical research; Middle Aged; Mineral Waters - virology; norovirus; Norovirus - pathogenicity; Spain - epidemiology; Viruses; Water; Waterborne Diseases - epidemiology; Waterborne Diseases - virology; Waterborne infections; Spain; GI; viruses; GII; 50% illness dose; genotypes; bottled mineral water; real-time quantitative PCR; Spain; water cooler; norovirus; waterborne outbreak; infectivity; dose causing illness; secretor status
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2601.190778

During a waterborne outbreak of norovirus in Spain, we estimated 50% illness doses for a group of exposed (secretor) persons to be 556 (95% CI 319-957) genome copies/day for norovirus GI and 2,934 (95% CI 1,683-5,044) genome copies/day for norovirus GII. Use of a propidium monoazide viability assay reduced these values.