Effect of Frequency-Dependent Attenuation on Predicted Histotripsy Waveforms in Tissue-Mimicking Phantoms

• Published in: Ultrasound in medicine & biology Vol. 42; no. 7; pp. 1701 - 1705
• Main Authors: Bader, Kenneth B, Crowe, Michael J, Raymond, Jason L, Holland, Christy K
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01-07-2016
• Subjects: Acoustical properties; Cavitation; Equipment Design; Histotripsy; Models, Biological; Phantoms, Imaging; Radiology; Shock waves; Ultrasonic attenuation; Ultrasonic Surgical Procedures - methods; Shock waves; Ultrasonic attenuation; Acoustical properties; Histotripsy; Cavitation
• ISSN: 0301-5629; 1879-291X
• DOI: 10.1016/j.ultrasmedbio.2016.02.010

Abstract Tissue-mimicking phantoms are employed for the assessment of shocked histotripsy pulses in vitro . These broadband shock waves are critical for tissue ablation and are influenced by the frequency-dependent attenuation of the medium. The density, sound speed and attenuation spectra (2–25 MHz) were measured for phantoms that mimic key histotripsy targets. The influence of non-linear propagation relative to the attenuation was described in terms of Gol'dberg number. An expression was derived to estimate the bandwidth of shocked histotripsy pulses for power law-dependent attenuation. The expression is independent of the fundamental frequency of the histotripsy pulse for linear frequency-dependent attenuation.