Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury

• Published in: Neural regeneration research Vol. 11; no. 2; pp. 257 - 261
• Main Authors: Peng, Shu-ping, Li, Yi-ning, Liu, Jun, Wang, Zhi-yuan, Zhang, Zi-shu, Zhou, Shun-ke, Tao, Fang-xu, Zhang, Zhi-xue
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 01-02-2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Radiology,Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China%Hunan Cancer Hospital,Changsha,Hunan Province,China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Blood flow; Brain injuries; Care and treatment; Coma; Complications and side effects; Consciousness; Data processing; Diagnosis; Magnetic resonance imaging; Software; Traumatic brain injury; 亚急性; 创伤性脑损伤; 动脉; 标记技术; 脉冲; 脑血流; 自旋标记法; 诊断依据; United States; Canada; Montreal Quebec Canada; United States > US; China; pulsed arterial spin labeling technique; CT; white matter; neural regeneration; Glasgow Coma Scale; MRI; gray matter; cerebral blood flow; nerve regeneration; mild traumatic brain injury
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.177733

Cerebral blood flow is strongly associated with brain function, and is the main symptom and diagnostic basis for a variety of encephalopathies. However, changes in cerebral blood flow after mild traumatic brain injury remain poorly understood. This study sought to observe changes in cerebral blood flow in different regions after mild traumatic brain injury using pulsed arterial spin labeling. Our results demonstrate maximal cerebral blood flow in gray matter and minimal in the white matter of patients with mild traumatic brain injury. At the acute and subacute stages, cerebral blood flow was reduced in the occipital lobe, parietal lobe, central region, subcutaneous region, and frontal lobe. Cerebral blood flow was restored at the chronic stage. At the acute, subacute, and chronic stages, changes in cerebral blood flow were not apparent in the insula. Cerebral blood flow in the temporal lobe and limbic lobe diminished at the acute and subacute stages, but was restored at the chronic stage. These findings suggest that pulsed arterial spin labeling can precisely measure cerebral blood flow in various brain regions, and may play a reference role in evaluating a patient＇s condition and judging prognosis after traumatic brain injury.