Disparities in clinical features and outcomes of peripartum cardiomyopathy in high versus low prevalent regions in Nigeria

• Published in: ESC Heart Failure Vol. 8; no. 4; pp. 3257 - 3267
• Main Authors: Karaye, Kamilu M., Ishaq, Naser A., Sai'du, Hadiza, Balarabe, Sulaiman A., Ahmed, Bashir G., Adamu, Umar G., Mohammed, Idris Y., Oboirien, Isa, Umuerri, Ejiroghene M., Mankwe, Abaram C., Shidali, Vincent Y., Dodiyi‐Manuel, Sotonye, Njoku, Paschal, Olunuga, Taiwo, Josephs, Veronica, Mbakwem, Amam C., Ogah, Okechukwu S., Tukur, Jamilu, Okeahialam, Basil, Stewart, Simon, Henein, Michael, Sliwa, Karen
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-08-2021; John Wiley and Sons Inc; Wiley
• Subjects: Cardiomyopathies - diagnosis; Cardiomyopathies - epidemiology; Cardiomyopathy; Clinical outcomes; Female; Geopolitics; Humans; Investigations; Mortality; Nigeria - epidemiology; Original; Original s; Outcomes; Peace; PEACE registry; Peripartum cardiomyopathy; Peripartum Period; Prevalence; Prospective Studies; Regional disparities; Regions; Selenium; Statistical analysis; Nigeria; Middle East; Regional disparities; Peripartum cardiomyopathy; Selenium; PEACE registry; Outcomes
• ISSN: 2055-5822; 2055-5822
• DOI: 10.1002/ehf2.13463

Aims
The prospective, multicentre Peripartum Cardiomyopathy in Nigeria (PEACE) registry originally demonstrated a high prevalence of peripartum cardiomyopathy (PPCM) among patients originating from Kano, North‐West Nigeria. In a post hoc analysis, we sought to determine if this phenomenon was characterized by a differential case profile and outcome among PPCM cases originating elsewhere.
Methods and results
Overall, 199 (81.6%) of a total 244 PPCM patients were recruited from three sites in Kano, compared with 45 patients (18.4%) from 11 widely dispersed centres across Nigeria. Presence and extent of ventricular myocardial remodelling during follow‐up, relative to baseline status, were assessed by echocardiography. During median 17 months follow‐up, Kano patients demonstrated significantly better myocardial reverse remodelling than patients from other sites. Overall, 50.6% of patients from Kano versus 28.6% from other regions were asymptomatic (P = 0.029) at study completion, with an accompanying difference in all‐cause mortality (17.6% vs. 22.2% respectively, P = 0.523) not reaching statistical significance. Alternatively, 135/191 (84.9%) of Kano patients had selenium deficiency (<70 μg/L), and 46/135 (34.1%) of them received oral selenium supplementation. Critically, those that received selenium supplementation demonstrated better survival (6.5% vs. 21.2%; P = 0.025), but the supplement did not have significant impact on myocardial remodelling.
Conclusions
This study has shown important non‐racial regional disparities in the clinical features and outcomes of PPCM patients in Nigeria, that might partly be explained by selenium supplementation.