Interaction between neonatal vitamin A supplementation and timing of measles vaccination: A retrospective analysis of three randomized trials from Guinea-Bissau

• Published in: Vaccine Vol. 32; no. 42; pp. 5468 - 5474
• Main Authors: Benn, Christine S, Martins, Cesario L, Fisker, Ane B, Diness, Birgitte R, Garly, May-Lill, Balde, Ibraima, Rodrigues, Amabelia, Whittle, Hilton, Aaby, Peter
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 22-09-2014; Elsevier; Elsevier Limited; Elsevier Science
• Subjects: Allergy and Immunology; Applied microbiology; Biological and medical sciences; Breastfeeding & lactation; Children; Children & youth; Dietary Supplements; Female; Fundamental and applied biological sciences. Psychology; Guinea-Bissau; Human viral diseases; Humans; Immunization; Immunization Schedule; Immunization, Secondary; Infant; Infectious diseases; Low-income countries; Male; Measles - prevention & control; Measles vaccine; Measles Vaccine - administration & dosage; Medical sciences; Microbiology; Mortality; Proportional Hazards Models; Retrospective Studies; Vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Vitamin A; Vitamin A - administration & dosage; Vitamin A - adverse effects; Guinea-Bissau; West Africa; Sub-Saharan Africa; Africa; Vitamin A; Low-income countries; Children; Measles vaccine; Mortality; Human; Tropical zone; Vaccination; Vitamin; Vaccine; Retinol; Infection; Viral disease; Measles; Child
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2014.07.090

Highlights • Early measles vaccine and neonatal vitamin A supplementation may become policy in low-income countries. • Vaccines and vitamin A may interact. • In children who received early measles vaccine, neonatal vitamin A was associated with 5-fold higher overall mortality. • Implementation of both policies at the same time may lead to increased child mortality. • Co-packaging of child health interventions should be investigated for the effect on overall mortality.