A Highly Efficient Chemiluminescence System Based on an Enhancing Effect of Ag Nanoclusters/Graphene Quantum Dots Mixture for Ultrasensitive Detection of Rabeprazole

• Published in: Analytical Sciences Vol. 35; no. 4; pp. 385 - 391
• Main Authors: YOUSEFZADEH, Ashraf, ABOLHASANI, Jafar, HASSANZADEH, Javad, SOMI, Mohammad Hossein
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 2019; Springer Nature Singapore; Japan Science and Technology Agency
• Subjects: Ag nanoclusters; amplifying effect; Analytical Chemistry; Biological properties; Biological samples; Chemiluminescence; Chemistry; Emission analysis; Fluorescence; Graphene; graphene quantum dots; Graphite - chemistry; Heat treatment; Luminescent Measurements; Metal Nanoparticles - chemistry; Nanoclusters; Nanomaterials; Organic chemistry; Oxidation; Particle Size; Potassium permanganate; Quantum dots; Quantum Dots - chemistry; rabeprazole; Rabeprazole - analysis; Rhodamine; Silver; Silver - chemistry; Surface Properties; rabeprazole; graphene quantum dots; Ag nanoclusters; chemiluminescence; amplifying effect
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.18P419

Herein, an efficient chemiluminescence (CL) reaction with a high emission intensity is reported based on a synergistic improving effect of silver nanoclusters (AgNCs) and graphene quantum dots (GQDs). First, the syntheses of AgNCs and GQDs were simply performed by the chemical reducing of AgNO3 and a thermal treatment of glucose, respectively. After the characterization steps, the beneficial behavior of the prepared nanomaterial was investigated in CL systems. The oxidation reaction of KMnO4-rhodamine B produced weak CL emission. However, the presence of AgNCs and GQDs led to a synergetic enhancing effect, and thus higher emission was obtained. A possible mechanism was investigated for this effect using absorption and fluorescence experiments. Furthermore, rabeprazole showed a relatively selective enhancing impact on the CL emission. The CL intensity was linearly increased in the rabeprazole concentration range of 4 – 133 ng mL−1 with a detection limit (3Sb/m) of 1.1 ng mL−1. The developed CL method was utilized for the measurement of Rbp in biological samples with acceptable precision and accuracy.