Relation of fibroblast growth factor-23 and cardiovascular calcification in end-stage kidney disease patients on regular hemodialysis

• Published in: Saudi journal of kidney diseases and transplantation Vol. 28; no. 1; pp. 51 - 60
• Main Authors: Abd al-Al, Husayn Shahin, Abd Allah, Abd Allah Mahmud, Abd al-Latif, Salamah Sad, Ghayth, Usamah Ashri Ahmad, Khamis, Usamah Ahmad, al-Baz, Tariq Zakariyya
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 2017; Wolters Kluwer India Pvt. Ltd; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adult; Age Factors; Aged; Analysis; Aortic Diseases - blood; Aortic Diseases - diagnostic imaging; Aortic Diseases - epidemiology; Aortography - methods; Biomarkers - blood; Care and treatment; Chronic kidney failure; Complications and side effects; Computed Tomography Angiography; Coronary Angiography - methods; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Cross-Sectional Studies; Egypt - epidemiology; Female; Fibroblast growth factors; Fibroblast Growth Factors - blood; Health aspects; Hemodialysis; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - therapy; Male; Middle Aged; Multidetector Computed Tomography; Prevalence; Renal Dialysis - adverse effects; Risk Factors; Treatment Outcome; Up-Regulation; Vascular Calcification - blood; Vascular Calcification - diagnostic imaging; Vascular Calcification - epidemiology; الأبهر البطني; الأمراض; الجهاز القلبي الوعائي; الكلى; المرضى; عوامل النمو; غسيل الكلى; Egypt; Saudi Arabia
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.198127

More than half of deaths in end-stage kidney disease (ESKD) patients are due to
cardiovascular disease. Elevated fibroblast growth factor 23 (FGF-23) was found to be associated
with mortality in hemodialysis (HD) patients and correlates with peripheral calcification. Aortic
calcification is associated with coronary artery calcification. Both aortic and peripheral vascular
calcifications were associated with mortality in chronic kidney disease. We aimed to investigate
the relation between intact FGF-23 and cardiovascular calcification in patients with ESKD who
were maintained on regular HD. Sixty clinically stable ESKD patients on regular HD were
enrolled into this cross-sectional study. They were evaluated by basal abdominal X-ray. They
were divided into two groups: (Group A, n = 30), patients with abdominal aortic calcification who
underwent multislice computerized tomography scan to measure coronary artery calcification
score; and (Group B, n = 30), patients without abdominal aortic calcification. All of them were
evaluated by lipid profile and dialysis adequacy parameters. Fifty percent of patients had vascular
calcification. We found a significant positive correlation between age and intact FGF-23;
significant positive correlations between age, body mass index, duration of HD, and abdominal
aortic calcification score. FGF-23 of all patients was elevated and had significant positive
correlation with aortic and coronary calcifications in addition to lipid profile, left ventricular
mass index (LVMI), and inflammatory markers. Plasma intact FGF-23 was elevated in nondiabetic