Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

• Published in: Nano-micro letters Vol. 12; no. 1; p. 103
• Main Authors: Sun, Yujia, Zheng, Liwei, Yang, Yu, Qian, Xu, Fu, Ting, Li, Xiaowei, Yang, Zunyi, Yan, He, Cui, Cheng, Tan, Weihong
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 02-05-2020; Springer Nature B.V; SpringerOpen
• Subjects: Biomedical applications; Biomedical materials; Biomolecules; Chemical compounds; Drug carriers; Drug delivery; Drug delivery systems; Drugs; Engineering; Metal-organic frameworks; Nanobiomedicine; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; Nucleic acids; Pharmacology; Pore size; Porosity; Review; Drugs; Biomolecules; Drug delivery; Biomedical applications; Metal–organic frameworks
• ISSN: 2311-6706; 2150-5551
• DOI: 10.1007/s40820-020-00423-3

Highlights
Recent advances in biomedical applications of metal–organic framework (MOF) nanocarriers for drug delivery are summarized.
State-of-the-art strategies to functionalize MOFs with therapeutic agents, as well as their merits and drawbacks, are comprehensively discussed.
Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. In this review, the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section. Then, state-of-the-art strategies to functionalize MOFs with therapeutic agents were summarized, including surface adsorption, pore encapsulation, covalent binding, and functional molecules as building blocks. In the third section, the most recent biological applications of MOFs for intracellular delivery of drugs, proteins, and nucleic acids, especially aptamers, were presented. Finally, challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.