Influence of acute exposure to a low dose of systemic insecticide fipronil on locomotor activity and emotional behavior in adult male mice

• Published in: Journal of Veterinary Medical Science Vol. 83; no. 2; pp. 344 - 348
• Main Authors: MAEDA, Mizuki, YOKOYAMA, Toshifumi, KITAUCHI, Sayaka, HIRANO, Tetsushi, MANTANI, Youhei, TABUCHI, Yoshiaki, HOSHI, Nobuhiko
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2021; The Japanese Society of Veterinary Science
• Subjects: behavioral test; fipronil; gamma-aminobutyric acid (GABA); insecticide; locomotor activity; Toxicology; fipronil; insecticide; locomotor activity; behavioral test; gamma-aminobutyric acid (GABA)
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.20-0551

Fipronil (FPN) is a systemic insecticide that antagonizes the gamma-aminobutyric acid type A (GABAA) receptors in insects. Recently, adverse effects of FPN on mammals have been reported, but most of those were caused by high doses of FPN and additives in the products. We investigated the effects of low-dose pure FPN on the emotional behavior of mice. Nine-week-old male mice conducted behavioral tests 24 hr after FPN administration by gavage at doses of 0.05 or 5 mg/kg based on the no-observed-effect level (NOEL), showed a significant increase in locomotor activity and dose-dependent responses on the time they spent in the central zone in the open field test. Pure FPN below the NOEL dose may affect the emotional behavior of mice.