The Impact of Maternal Passive Tobacco Smoke on Neonatal Myocardiopathy in Mice

• Published in: Birth defects research Vol. 116; no. 11; p. e2411
• Main Authors: Kawish, Naseer, Abbasi, Muddasir Hassan, Khawar, Muhammad Babar, Akhtar, Tasleem, Arif, Amin, Majid, Ayesha, Sheikh, Nadeem
• Format: Journal Article
• Language: English
• Published: 01-11-2024
• ISSN: 2472-1727; 2472-1727
• DOI: 10.1002/bdr2.2411

Tobacco smoke has a global impact, particularly on pregnant women and their newborns. An emerging body of research suggests that passive tobacco smoking is a significant contributor to congenital cardiovascular disorders (CVDs).BACKGROUNDTobacco smoke has a global impact, particularly on pregnant women and their newborns. An emerging body of research suggests that passive tobacco smoking is a significant contributor to congenital cardiovascular disorders (CVDs).This study aimed to mimic the effects of passive tobacco smoke (PTS) on neonates exposed throughout the gestational period.AIM OF THE STUDYThis study aimed to mimic the effects of passive tobacco smoke (PTS) on neonates exposed throughout the gestational period.Female mice (DPC = 0) were exposed to PTS; 24 cigarettes/day with an interval of 10 min between each cigarette in a specialized smoke chamber from conception to birth. Histopathological analysis was employed to evaluate PTS-induced cardiac damage in neonates.METHODSFemale mice (DPC = 0) were exposed to PTS; 24 cigarettes/day with an interval of 10 min between each cigarette in a specialized smoke chamber from conception to birth. Histopathological analysis was employed to evaluate PTS-induced cardiac damage in neonates.The results revealed significant alterations in cell structure, namely, widened interstitial spaces, hemorrhage, pyknotic nuclei, inflammatory cell infiltration, collagen deposition, and fibrosis.RESULTSThe results revealed significant alterations in cell structure, namely, widened interstitial spaces, hemorrhage, pyknotic nuclei, inflammatory cell infiltration, collagen deposition, and fibrosis.Maternal exposure to PTS during pregnancy may lead to neonatal myocardiopathy.CONCLUSIONMaternal exposure to PTS during pregnancy may lead to neonatal myocardiopathy.