The dual role of methylglyoxal in plant stress response and regulation of DJ ‐1 protein

• Published in: Physiologia plantarum Vol. 176; no. 6; p. e14608
• Main Authors: Sun, Yutong, Chen, Sixue, Grin, Inga R., Zharkov, Dmitry O., Yu, Bing, Li, Haiying
• Format: Journal Article
• Language: English
• Published: 01-11-2024
• ISSN: 0031-9317; 1399-3054; 1399-3054
• DOI: 10.1111/ppl.14608

Methylglyoxal (MG) is a highly reactive metabolic intermediate that plays important roles in plant salt stress response. This review explores the sources of MG in plants, how salt stress promotes MG production, and the dual role of MG under salt stress conditions. Both the positive role of low concentrations of MG as a signalling molecule and the toxic effects of high concentrations of MG in plant response to salt stress are discussed. The MG detoxification pathways, especially the glyoxalase system, are described in detail. Special attention is given to the novel role of the DJ‐1 protein in the glyoxalase system as glyoxalase III to remove MG, and as a deglycase to decrease glycation damage caused by MG on DNA, proteins, and other biomolecules. This review aims to provide readers with comprehensive perspectives on the functions of MG in plant salt stress response, the roles of the DJ‐1 protein in MG detoxification and repair of glycation‐damaged molecules, as well as the broader functional implications of MG in plant salt stress tolerance. New perspectives on maintaining plant genome stability, breeding for salt‐tolerant crop varieties, and improving crop quality are discussed.