The Management of Thrombosis in the Antiphospholipid-Antibody Syndrome

• Published in: The New England journal of medicine Vol. 332; no. 15; pp. 993 - 997
• Main Authors: Khamashta, Munther A, Cuadrado, Maria Jose, Mujic, Fedza, Taub, Nick A, Hunt, Beverley J, Hughes, Graham R.V
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 13-04-1995
• Subjects: Adolescent; Adult; Anticoagulants; Anticoagulants - therapeutic use; Antiphospholipid antibodies; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - drug therapy; Aspirin; Aspirin - therapeutic use; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Drug therapy; Female; Follow-Up Studies; Hemorrhage; Hospitals; Humans; Immunity (Disease); Immunoglobulins; Lupus; Lupus Erythematosus, Systemic - complications; Male; Medical imaging; Medical research; Medical sciences; Middle Aged; Patients; Pharmacology. Drug treatments; Recurrence; Retrospective Studies; Systemic lupus erythematosus; Thrombosis; Thrombosis - etiology; Thrombosis - prevention & control; Warfarin; Warfarin - therapeutic use; Human; Immunopathology; Connective tissue disease; Skin disease; Antiphospholipid antibody syndrome; Treatment efficiency; Cardiovascular disease; Autoimmune disease; Anticoagulant; Thrombosis; Artery; Venous disease; Arterial disease; Vascular disease; Chemotherapy; Treatment; Systemic disease; Therapeutic protocol; Vein
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199504133321504

The antiphospholipid-antibody syndrome is a thrombophilic disorder in which venous or arterial thrombosis, or both, may occur.
1
The serologic markers of the syndrome are antiphospholipid antibodies (anticardiolipin antibodies, the lupus anticoagulant, or both).
The antiphospholipid-antibody syndrome often occurs in systemic lupus erythematosus, but the majority of patients with the syndrome do not meet the criteria for that disease.
2
Thus, the combination of recurrent thrombosis and antiphospholipid antibodies in patients without features of lupus is called the primary antiphospholipid syndrome.
3
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5
Other important features of the syndrome are thrombocytopenia and recurrent spontaneous abortion.
Thrombosis, the main complication of the antiphospholipid-antibody syndrome, . . .