Functions of N6-methyladenosine and its role in cancer

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differen...

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Bibliographic Details
Published in:	Molecular cancer Vol. 18; no. 1; p. 176
Main Authors:	He, Liuer, Li, Huiyu, Wu, Anqi, Peng, Yulong, Shu, Guang, Yin, Gang
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 04-12-2019 BioMed Central BMC
Subjects:	Adenosine Apoptosis Autophagy Biochemistry Cancer Cancer research Cell cycle Cell differentiation Cell growth Cell self-renewal Cyclin-dependent kinases Dendritic cells Development and progression Enzymes Epidermal growth factor receptors eraser Gene expression Genes Health aspects Homeostasis Immunotherapy Kinases Melanoma Messenger RNA Metabolism Methylation Methyltransferases MicroRNA MicroRNAs miRNA Myc protein N6-methyladenosine Pathogenesis Physiological aspects Physiology Proteins reader Review RNA RNA modification RNA polymerase Splicing Stem cells Translation (Genetics) Tumorigenesis Tumors writer Writers eraser N6-methyladenosine cancer writer reader
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Summary:	N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A is installed by m6A methyltransferases, removed by m6A demethylases and recognized by reader proteins, which regulate of RNA metabolism including translation, splicing, export, degradation and microRNA processing. Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR. In this review, we elaborate on recent advances in research of m6A enzymes. We also highlight the underlying mechanism of m6A in cancer pathogenesis and progression. Finally, we review corresponding potential targets in cancer therapy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1476-4598 1476-4598
DOI:	10.1186/s12943-019-1109-9