Metabolic changes in aging humans: current evidence and therapeutic strategies

• Published in: The Journal of clinical investigation Vol. 132; no. 16; pp. 1 - 8
• Main Authors: Palmer, Allyson K, Jensen, Michael D
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15-08-2022
• Subjects: Adipose Tissue; Aged; Aging; Aging - metabolism; Biomedical research; Body composition; Body fat; Caloric Restriction; Dietary restrictions; Drug metabolism; Health aspects; Humans; Longitudinal studies; Metabolism; Obesity; Older people; Physical training; Physiological aspects; Review Series; Sarcopenia; Sarcopenia - therapy; Therapeutic applications; Young adults; United States
• ISSN: 1558-8238; 0021-9738; 1558-8238
• DOI: 10.1172/JCI158451

Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues - adipose, muscle, and liver - as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.