Evaluation of reporting quality of randomized controlled trials in patients with COVID-19 using the CONSORT statement

• Published in: PloS one Vol. 16; no. 9; p. e0257093
• Main Authors: Yin, Yuhuan, Shi, Fugui, Zhang, Yiyin, Zhang, Xiaoli, Ye, Jianying, Zhang, Juxia
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 23-09-2021; Public Library of Science (PLoS)
• Subjects: Authorship; Clinical trials; Complications and side effects; Coronaviruses; COVID-19; Decision making; Endorsements; Evaluation; Evidence-based medicine; Impact factors; Literature reviews; Medical research; Medicine; Medicine and Health Sciences; Nursing schools; Patient outcomes; Patients; Physical Sciences; Regression analysis; Research and Analysis Methods; Statistical analysis; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0257093

Objective To evaluate the reporting quality of randomized controlled trials (RCTs) regarding patients with COVID-19 and analyse the influence factors. Methods PubMed, Embase, Web of Science and the Cochrane Library databases were searched to collect RCTs regarding patients with COVID-19. The retrieval time was from the inception to December 1, 2020. The CONSORT 2010 statement was used to evaluate the overall reporting quality of these RCTs. Results 53 RCTs were included. The study showed that the average reporting rate for 37 items in CONSORT checklist was 53.85% with mean overall adherence score of 13.02±3.546 (ranged: 7 to 22). The multivariate linear regression analysis showed the overall adherence score to the CONSORT guideline was associated with journal impact factor (P = 0.006), and endorsement of CONSORT statement (P = 0.014). Conclusion Although many RCTs of COVID-19 have been published in different journals, the overall reporting quality of these articles was suboptimal, it can not provide valid evidence for clinical decision-making and systematic reviews. Therefore, more journals should endorse the CONSORT statement, authors should strictly follow the relevant provisions of the CONSORT guideline when reporting articles. Future RCTs should particularly focus on improvement of detailed reporting in allocation concealment, blinding and estimation of sample size.