Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation

• Published in: Journal of immunology research Vol. 2016; no. 2016; pp. 1 - 17
• Main Authors: Nenasheva, Tatiana, Nikolaev, Alexander, Sosunova, Ekaterina, Lyadova, I. V.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2016; Hindawi Limited
• Subjects: Amino acids; Animals; Biomarkers; Cancer; Cell cycle; Cell Differentiation; Cytokines - metabolism; Dendritic cells; Disease; Enzymes; Gene Expression Regulation; Humans; Immune System - cytology; Immune System - immunology; Immune System - metabolism; Immunology; Immunomodulation - genetics; Kinases; Lymphocyte Subsets - immunology; Lymphocyte Subsets - metabolism; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - immunology; Mesenchymal Stromal Cells - metabolism; Myeloid-Derived Suppressor Cells - immunology; Myeloid-Derived Suppressor Cells - metabolism; Oxidation-Reduction; Pathology; Review; Stem cells
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2016/7121580

To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.