The Serum Mac-2-binding Protein Glycosylation Isomer Dynamics in Acute Liver Injury

• Published in: Internal Medicine Vol. 59; no. 13; pp. 1581 - 1588
• Main Authors: Seike, Takuya, Komura, Takuya, Shimizu, Yoshiaki, Omura, Hitoshi, Kumai, Tatsuo, Kagaya, Takashi, Ohta, Hajime, Kawashima, Atsuhiro, Harada, Kenichi, Kaneko, Shuichi, Unoura, Masashi
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01-07-2020; Japan Science and Technology Agency
• Subjects: acute liver injury; Alanine; Alanine transaminase; Alkaline phosphatase; Bilirubin; Diagnosis; Etiology; Glycosylation; Infectious mononucleosis; Internal medicine; Liver; M2BPGi; Mononucleosis; Multivariate analysis; Original; WFA+-M2BP; Wisteria floribunda agglutinin-positive human Mac-2-binding protein; WFA+-M2BP; M2BPGi; Wisteria floribunda agglutinin-positive human Mac-2-binding protein; acute liver injury
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.3867-19

Objective We aimed to examine the dynamics of serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein glycosylation isomer (M2BPGi) in patients with acute liver injury. Methods Serum M2BPGi levels at the time of the diagnosis (n=77) and normalization of the serum alanine aminotransferase (ALT) level (n=26) were examined retrospectively. The difference in the serum M2BPGi level according to the etiology, and the correlations with other laboratory parameters were evaluated. Results The serum M2BPGi level at the time of the diagnosis was increased in 59 of 77 patients [2.3 cutoff index (COI); range, 0.31-11.1 COI] and was significantly decreased at the time of serum ALT normalization (0.68 COI; range, 0.15-1.87 COI; p<0.0001). The serum M2BPGi level was positively correlated with the duration for which serum ALT normalization was achieved (n=46, Spearman rho=0.53, p<0.0001). A multivariate analysis identified total bilirubin (T-bil), albumin, ALT, alkaline phosphatase, and etiology (e.g., drug-induced liver injury or etiology unknown) as independent factors for increased serum M2BPGi. In patients with infectious mononucleosis, the serum M2BPGi level was higher relative to the degree of increase of serum ALT or T-bil levels in comparison to other etiologies. Conclusion The serum M2BPGi level in patients with acute liver injury reflects the magnitude and duration of liver injury. However, it should be noted that the degree of increase of serum M2BPGi in patients with acute liver injury may differ according to the etiology.