Effects of fenugreek seed extract in obese mice fed a high-fat diet

• Published in: Bioscience, biotechnology, and biochemistry Vol. 69; no. 6; pp. 1186 - 1188
• Main Authors: Handa, T. (Tokyo Univ. or Marine Science and Technology (Japan)), Yamaguchi, K, Sono, Y, Yazawa, K
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01-06-2005; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: 4-hydroxyisoleucine; Adipose Tissue - drug effects; Animals; Anti-Obesity Agents - pharmacology; Biological and medical sciences; BLOOD PLASMA; BODY WEIGHT; DIET; Dietary Fats; FATS; Female; fenugreek; Fundamental and applied biological sciences. Psychology; high-fat diet; ISOLEUCINE; Liver - drug effects; MICE; Mice, Obese; obesity; Organ Size - drug effects; OVERWEIGHT; Plant Extracts - chemistry; Plant Extracts - pharmacology; SEED EXTRACTS; Seeds - chemistry; triglyceride; TRIGLYCERIDES; Triglycerides - blood; Trigonella - chemistry; TRIGONELLA FOENUM GRAECUM; Weight Gain; Rodentia; Extract; fenugreek; Triglyceride; Vertebrata; Mammalia; Leguminosae; Diet; Mouse; Dicotyledones; Angiospermae; high-fat diet; ohesity; 4-hydroxyisoleucine; Spermatophyta; Trigonella foenum graecum
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.69.1186

It was found that fenugreek seed extract reduced the body weight gain induced by a high-fat diet in obese mice. The extract decreased plasma triglyceride gain induced by oil administration. The major component of the extract, 4-hydroxyisoleucine, also decreased plasma triglyceride gain. Consequently, fenugreek seed extract is expected to prevent the obesity induced by a high-fat diet.