Pulmonary Embolism and Increased Levels of d -Dimer in Patients with Coronavirus Disease

Conversely, using a rat model, Nosaka et al. demonstrated the importance of iIL-6 in resolving thrombi through macrophage recruitment and proteolytic enzymes induction (4). The absence of IL-6, in fact, leads to the thrombus growing (4). [...]tocilizumab has been reported to decrease factor XIII, ch...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 26; no. 10; pp. 2532 - 2533
Main Authors:	Chan, Kok Hoe, Slim, Jihad, Shaaban, Hamid S
Format:	Journal Article
Language:	English
Published:	Atlanta U.S. National Center for Infectious Diseases 01-10-2020 Centers for Disease Control and Prevention
Subjects:	Blood clots Coronavirus infections Coronaviruses COVID-19 Cytokine storm Enzymes Factor XIII deficiency interleukin-6 receptor Letter Letters to the Editor plasminogen activator proteolytic enzymes Pulmonary embolism Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease Pulmonary embolisms Thromboembolism Thrombosis United States > US New Jersey
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Summary:	Conversely, using a rat model, Nosaka et al. demonstrated the importance of iIL-6 in resolving thrombi through macrophage recruitment and proteolytic enzymes induction (4). The absence of IL-6, in fact, leads to the thrombus growing (4). [...]tocilizumab has been reported to decrease factor XIII, chemerin, and plasminogen activator inhibitor levels (5). Factor XIII is involved in fibrin stabilization; blocking this factor may lead to fibrin clot instability, causing microthrombi to dislodge, increasing the likelihood of thrombophilia.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2610.202127